Novel Associations of Nonstructural Loci with Paraoxonase Activity
نویسندگان
چکیده
منابع مشابه
Novel Associations of Nonstructural Loci with Paraoxonase Activity
The high-density-lipoprotein-(HDL-) associated esterase paraoxonase 1 (PON1) is a likely contributor to the antioxidant and antiatherosclerotic capabilities of HDL. Two nonsynonymous mutations in the structural gene, PON1, have been associated with variation in activity levels, but substantial interindividual differences remain unexplained and are greatest for substrates other than the eponymou...
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Human serum paraoxonase (PON) associated with high density lipoprotein (HDL) , has been postulated to have a role in protecting low-density lipoprotein (LDL) against oxidative damage, which has led to the proposal that PON is an anti-atherogenic and anti-inflammatory enzyme. It has genetic polymorphism at the 191 (R ->Q) and two alloenzymes A and B and three phenotypes A, B, and AB. We exa...
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ژورنال
عنوان ژورنال: Journal of Lipids
سال: 2012
ISSN: 2090-3030,2090-3049
DOI: 10.1155/2012/189681